Single-cell morphology encodes metastatic potential

A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and tissues. Cell morphology is an emergent readout of the molecular underpinnings of a cell’s functions and, thus, can be used as a method to define the functional state of an individual cell. We measured 216 features derived from cell and nucleus morphology for more than 30,000 breast cancer cells. We find that single cell–derived clones (SCCs) established from the same parental cells exhibit distinct and heritable morphological traits associated with genomic (ploidy) and transcriptomic phenotypes. Using unsupervised clustering analysis, we find that the morphological classes of SCCs predict distinct tumorigenic and metastatic potentials in vivo using multiple mouse models of breast cancer. These findings lay the groundwork for using quantitative morpho-profiling in vitro as a potentially convenient and economical method for phenotyping function in cancer in vivo. Much effort is being made to explore the predictive power of genomic alterations in the detection and prognosis of diseases (1–4). However, a high degree of genomic inst...

UAE news: Medal design for the 2020 Ras Al Khaimah Half Marathon unveiled

The eagerly anticipated medal design for the fastest half marathon in the world – the Ras Al Khaimah Half Marathon – has been revealed as event organsiers, Ras Al Khaimah Tourism and Development Authority (RAKTDA), announce that over 1,000 runners have already registered for the sporting event taking place on 21st February 2020 on Al Marjan Island. The Ras Al Khaimah Half Marathon has commissioned four medals for the 2020 edition of the world-renowned race – one for each of the categories. Crafted in metal, each medal is engraved with the category and embossed with the individual race distance. While the Half Marathon and Relay medals boast an impressive 90mm diameter with a stylised rotating disk in the middle, the 5KM and 1KM medal designs are solid discs measuring 80mm and 70mm respectively and bear the eye-catching, iconic logo of the event. The medals are made complete with colourful, individual ribbons for each category. On course to be the biggest ever edition of the event with a record number of participants, the family-friendly race will host a number of categories including; the half marathon, two- and four-person relay, 5km and 1km Kids Run. In particular, the relay a...

Caoa Chery vai lançar um SUV e um sedã no Brasil ainda este ano

O Grupo Caoa revolucionou a marca Chery no Brasil com modelos mais modernos e interessantes. E mais um SUV e um sedã estão por vir em 2020 A marca Chery, que é uma potência na China, chegou discretamente ao Brasil, construiu uma fábrica em Jacareí, no interior de São Paulo, e discreta ficou, até que veio o ‘golpe de mestre’ do Grupo Caoa. HONDA O Grupo Caoa comprou dos chineses a metade da fábrica da Chery, mudou os modelos, aumentou a qualidade e a rede de concessionárias. E já tem mais, pelo menos, dois modelos a serem lançados neste ano. Mais um sedã, que será o Arrizo 6, para concorrer na faixa do Civic e Corolla, e será produzido na fábrica de Jacareí. E outro, um utilitário esportivo, o Tiggo 8, com sete lugares, a ser produzido na fábrica de Caoa em Anápolis, Goiás. O motor será, provavelmente, um 1.6 turbo de 200 cavalos. Jornalista e engenheiro com 50 anos de rodagem na imprensa automotiva. Comandou equipes de jornais, televisão e apresenta o programa AutoPapo em emissoras de rádio em todo o país. Steering Rack, Lhd Steering Rack, Steering Pump, Drive Shaft, Propeller Shaft – Naifu,http://www.nfyo.com/

Dallas Invents: 136 Patents Granted for Week of May 28 » Dallas Innovates

Dallas-Fort Worth ranked No. 10 for patent activity out of 250 metros. Patents granted include: •  USAA’s self-charging unmanned vehicle •  Futurewei’s wearable antenna array •  Chama Chairs’ collapsible swivel chair •  ROKA Sports’ eyeglasses •  Taylor Made’s golf club with a sole stress-reducing feature •  Avodah Labs’ automated gesture identification using neural networks Dallas Invents is a weekly look at U.S. patents granted with a connection to the Dallas-Fort Worth-Arlington metro area. Listings include patents granted to local assignees and/or those with a North Texas inventor. Patent activity can be an indicator of future economic growth, as well as the development of emerging markets and talent attraction. By tracking both inventors and assignees in the region, we aim to provide a broader view of the region’s inventive activity. Listings are organized by Cooperative Patent Classification (CPC).  Texas Instruments Inc. (Dallas) 18 Futurewei Technologies, Inc. (Plano) 13 Doskocil Manufacturing Company Inc. (Arlington) 3 Mary Kay Inc. (Addison) 3 Toyota Motor Engineering Manufacturing North America Inc. (Plano) 3 Bell Helicopter Textron...

Best table lamps to light up homes in style this season

From focused task lights to more statuesque designs with shades, the right table lamp can change the feel of any room – helping to alter the ambience at the flick of a switch. There are many – excuse the pun – ‘elements’ to consider before buying a lamp. For example in a bedroom you can afford to opt for a more intimate, small light that’s not going to crowd a bedside table. Whereas, in a living room, you might choose a more statement lamp, to add a decorative feature – either with an intricate and ornamental base, or a bold, embellished shade – or both. Large lighting in strong colours can create a statement whereas smaller, more neutral versions will blend effortlessly into the background casting a gentle glow, without distracting the eye. You should also consider the two personalities a table lamp takes on. Be sure you are happy with how your chosen design looks both unlit during the day and then lit at night. The bulb plays a role here. Depending on whether it is a cool or warm light, it will influence how the colour of the shade looks in different ways, particularly if that shade is a bold colour. Whether you are a lover of dramatic designs or prefer a classic subtle style...

The HP Sprocket is one versatile photo printer that allows you to capture and share pictures

The HP Sprocket is one versatile photo printer that allows you to capture and share pictures instantly. DO you remember the last time you had your photographs printed? I certainly can’t. It was ages ago when cameras were still using film. And I no longer use those digital single-lens reflex (dLSR) cameras or the digital compact cameras. My “equipment” of choice is the camera phones. The iOS or Android phone (I have both, by the way) has served me well. Also, the Internet offers electronic albums where the photos can be kept and shared with family members and friends at a push of a button. The Sprocket is HP’s mini printer — yes, the size is as small or as big (whichever way you see it) as my mobile phone. It has been described as a “portable instant printer that prints photos from the phone.” It does not however print the standard 10cm x 15cm size photograph but on the special 5cm x 7.6cm Zink sticky-backed photo sheets. Zink stands for Zero Ink, which means that the Sprocket does not need any ink to print the photographs. Zink’s proprietary printing technology puts crystals on every sheet that show up as specific colours when they’re heated up. The Sprocket is rechargeable thr...

School is back in session, as Sex Education’s second season has hit Netflix. The U.K.-set dramedy

School is back in session, as Sex Education’s second season has hit Netflix. The U.K.-set dramedy returns with all the things you loved about the first season — stellar performances from its ensemble cast! British accents! High school nostalgia! Adorkable teens! — and even more of the things that, if you’re like me, made you cringe — horribly awkward parent-child conversations! Immensely humiliating, raw, and over-the-top sex crises! Let’s dive into all the wonderfully weird and wild action that unfolds on Sex Education’s newest installment. In last season’s finale, Moordale High’s resident virgin sex therapist Otis Milburn (Asa Butterfield) finally masturbated — but now he can’t stop and keeps getting accidental erections. A montage of these incidents — in the shower, during an assembly, while biking home — culminates in Otis pleasuring himself in his mother’s car while she runs into the store. As he climaxes, his mother returns and, well, things get messy. Amid dealing with that, Otis begins worrying about his girlfriend Ola finding out about his problem. When he eventually tells her, though, she is unphased and says they’ll deal with it together. #Couplegoals? As rosy as that...

Fotis Dulos, Murder Suspect, Found Unconscious in Attempted Suicide

The best in culture from a cultural icon. Subscribe now for more from the authority on music, entertainment, politics and pop culture. Fotis Dulos stands during a hearing at Stamford Superior Court, Tuesday, June 11, 2019 in Stamford, CT. Fotis Dulos, the estranged husband and suspected murderer of a Connecticut woman who was reported missing last May, was found unconscious at his home following an attempted suicide. Although initial media reports stated he was dead and his family had been notified of his death, his lawyer Norm Pattis told the Hartford Courant that he was “en route to the hospital with a pulse. Our thoughts and prayers are with him.” Dulos, 52, was charged earlier this month in the murder of Jennifer Dulos, his estranged wife and the mother of his five children. At the time Dulos was found at his home, he was expected to appear in court for an emergency bond hearing. Jennifer Dulos was last seen this past spring dropping off her kids at school in New Canaan, Connecticut, and was reported missing after she failed to show up for appointments in New York. Although her body has not been recovered, her blood was found in the garage of her home, and her car was found ...

In 2015, the American Water Works Association named Big Sky’s drinking water the best-tasting in the

In 2015, the American Water Works Association named Big Sky’s drinking water the best-tasting in the country. Pulled from deep underground, our water contains sweet-tasting minerals like calcium and magnesium. These minerals are perfectly healthy for human consumption, but they can wreak havoc on our home appliances. They can shorten the lifespan of everything from showerheads to hot-water heaters, and they give our teapots and faucets that unattractive white, crusty coating. Because of these minerals, our water is known as “hard water.” To soften it, we often install filtration systems that utilize salt, but the time has come for a change. Why, you might wonder, should you care at all about your water-filtration system? As long as the water is safe to drink, what is the difference? For one, salt-based filtration systems waste tons of water—literally. The Wilson Hotel recently installed a new, salt-less system and their water savings are estimated at 250,000 gallons annually. That’s a lot of water, and a huge cost savings to boot. In a salt-based system, healthy calcium and magnesium are replaced by equal parts of sodium, and the significant volume of water used in this process ...

The food retailer, which installed the first transcritical CO2 system in a U.S. supermarket, is now

The food retailer, which installed the first transcritical CO2 system in a U.S. supermarket, is now deploying one of the first in a U.S. retail warehouse. Hannaford, a Scarborough, Maine (U.S.)-based diviion of Ahold Delhaize, has the distinction of installing the first transcritical CO2 booster refrigeration in a U.S. supermarket, at a store in Turner, Maine, in July 2013. Now, Hannaford is about to become one of the first U.S. grocers to employ a transcritical CO2 system in a refrigerated warehouse. (The first known to do so was Angelo Caputo’s Fresh Markets, which installed a transcritical system at a warehouse/commissary in Carol Stream, Illinois, U.S., also in July 2013; a store was later added to that facility; see “In Love with CO2,” Accelerate America, June 2015.) Hannaford’s CO2 warehouse, located in Shodack Landing, New York (U.S.) – 20 miles east of Albany, New York – also contains one of the world’s largest refrigerated spaces (250,000ft2/23,226m2) to use a transcritical system, supplied by Quebec, Canada- based Carnot Refrigeration. The warehouse supplies 85 of Hannaford’s approximately 190 stores in New York, New Hampshire, Vermont and Massachusetts. Harrison Horni...

Constant Temperature and Humidity Chamber Industry Market Share, Growth Forecast- Global Industry Outlook

The Global Constant Temperature and Humidity Chamber Industry Market report provides a holistic evaluation of the market for the forecast period (2019–2025). The report comprises of various segments as well an analysis of the trends and factors that are playing a substantial role in the market. These factors; the market dynamics, involves the drivers, restraints, opportunities and challenges through which the impact of these factors in the market are outlined. The drivers and restraints are intrinsic factors whereas opportunities and challenges are extrinsic factors of the market. The Global Constant Temperature and Humidity Chamber Industry Market study provides an outlook on the development of market in terms of revenue throughout the prognosis period. Request Exclusive Free Sample PDF Of This Report At https://www.upmarketresearch.com/home/requested_sample/92058 Global Constant Temperature and Humidity Chamber Industry Market: Scope of the ReportThis report provides an all-inclusive environment of the analysis for the Global Constant Temperature and Humidity Chamber Industry Market. The market estimates provided in the report are the result of in-depth secondary research, pri...

Global Pin Header Market: Development History, Current Analysis and Estimated Forecast to 2025

The global Pin Header market is valued at million US$ in 2018 is expected to reach million US$ by the end of 2025, growing at a CAGR of during 2019-2025. Access Report Details at: https://www.themarketreports.com/report/global-pin-header-market-research-report This report focuses on Pin Header volume and value at global level, regional level and company level. From a global perspective, this report represents overall Pin Header market size by analyzing historical data and future prospect. Regionally, this report focuses on several key regions: North America, Europe, China and Japan. Key companies profiled in Pin Header Market report are Pololu, Te Connectivity, Amphenol, Molex, Foxconn, Jae, Delphi, Samtec, Jst, Hirose, Harting, Erni Electronics, Kyocera Corporation, Advanced Interconnect, Harwin and more in term of company basic information, Product Introduction, Application, Specification, Production, Revenue, Price and Gross Margin (2014-2019), etc. Connectors, Cable Assemblies And Wire Harnesses – YYE,http://www.yyecon.com/

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